2023Äê3ÔÂ17ÈÕ£¬Ò½Ñ§Ôº³ÂÁÁ½ÌÊÚÓë¿Õ¾ü¾üÒ½´óѧÖìÆ½½ÌÊÚ¡¢Ö£ÖÝ´óѧÑî¾²»ª½ÌÊÚºÏ×÷£¬ÒÔ¹²Í¬Í¨Ñ¶×÷ÕßÔÚ¹ú¼Ê¶¥¼¶Ñ§ÊõÆÚ¿¯¡¶Science¡·Éϰ䷢ÌâΪ¡°Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity¡±µÄ×êÑÐÂÛÎÄ¡£Ð±¦GGΪÂÛÎĵĹ²Í¬Í¨Ñ¶µ¥Ôª¡¢µÚ¶þʵÏÖµ¥Ôª¡£

ǿֱÐÔ¼¹ÖùÑ×£¨AS£©ÊÇÒ»ÖÖ×ÔÉíÃâÒßÐÔ¼²²¡£¬Æä·¢²¡»úÔìÉæ¼°µ½ÈËÌåÄÚÐÂÉúµÄ×ÔÉí¿¹Ô·ÛËéÃâÒßÄÍÊÜ£¬´Ó¶øÒý·¢¿¹ÔÌØÒìÐÔÃâÒß·´Ó³£¬µ¼Ö¶à¸öÆ÷¹ÙÊÜËð¡£µ°°×ÖʵķÒëºó½¨ÊΣ¨PTMs£©ÊÇÒ»ÖÖÉúÎïѧ¾°Ïó£¬Äܹ»Å¤×ªµ°°×ÖʵĽṹºÍÖ°ÄÜ£¬´Ó¶øÒý·¢ÐÂÉú¿¹Ô£¨neoantigen£©µÄ²úÉú£¬½ø¶øÒý·¢×ÔÉíÃâÒß·´Ó³¡£Ö®Ç°µÄ×êÑÐÒѾ֤ʵ£¬¹Ï°±ËὨÊÎëÄÊÇÀà·çʪ¹Ø½ÚÑ××ÔÉíÃâÒß·´Ó³µÄÒ»¸ö³ÁÒªÆðÔ´¡£È»¶ø£¬AS²úÉúÐÂÉú¿¹Ô¼°×ÔÉíÃâÒß·´Ó³µÄ·Ö×Ó»úÔìÈÔ²»ÎªÈËÃÇËùÖª¡£

¸Ã×êÑгõ´Î·¢ÏÖ²¢¼ø¶¨ÁËÒ»ÖÖȫеĵ°°×ÖÊ·Òëºó½¨ÊΣ¨PTM£©¡ª¡ª°ëë×°±ËáôÈ»ùÒÒ»ù»¯½¨ÊΡ£µ±°ëë×°±ËáÓë3-ôÇ»ù±ûËᣨ3-HPA£©½áºÏÐγÉÁòÃѼüʱ£¬¾Í»á²úÉú°ëë×°±ËáôÈÒÒ»ù»¯½¨ÊΣ¬ÕâÒ»·´Ó³±ØÒªÓÉë×Áò´¼¦ÂºÏø´ß»¯¡£ÔÚÕâЩ½¨ÊÎÖУ¬ÕûºÏËØ96λ°ëë×°±ËᣨITGA2B-96Cys£©µÄôÈÒÒ»ù»¯½¨Ê줻îÁËÈÜøÌå½µ½âõè¾¶£¬²úÉúôÈÒÒ»ù»¯ITGA2B½¨ÊÎëÄ£¬²¢¼ÓÇ¿ÁËHLA-DR4¸´ºÏÎïÖиý¨ÊÎëĵÄÕÙļ¡£ÕâÖÖ½¨ÊÎëÄÊÇCD4+ Tϸ°û·´Ó³Ãô¸ÐµÄÐÂÉú¿¹Ô£¬¿ÉÒýÆðÈËÀà°×ϸ°û¿¹Ô£¨HLA£©ÃâÒß·´Ó³¡£¸Ã×êÑÐÁ˾ֽÒʾÁËAS×ÔÉíÃâÒß²¡·¢²¡µÄȫзÖ×Ó»úÔì¡£
´Ë±í£¬¸Ã×êÑл¹·¢ÏÖ°ëë×°±ËáôÈÒÒ»ù»¯½¨ÊÎÊÇ´úл²úÆ·3-HPAÒýÆðµÄÒ»ÖÖÐÂÐ͵°°×½¨Êδó¾Ö¡£ôÈÒÒ»ù»¯½¨ÊεÄITGA2B¿ÉÄÜÓÕµ¼AS²úÉú½¨ÊÎÐÍÐÂÉú¿¹Ô£¬´Ó¶øµ¼ÖÂÌØÒìÐÔ×ÔÉíÃâÒß·´Ó³¡£±¾×êÑÐÌṩÁËÒ»ÖÖϵͳµÄ²½ÖèÕ½Êõ¡ª¡°²î¾à½¨Êε°°×-½¨ÊÎÐÍÐÂÉú¿¹Ô¡±£¬Îª¹¥¿Ë³Á´ó×ÔÉíÃâÒß²¡ÌṩÁËеÄ˼·¡£´Ë×êÑгõ´Î½ÒʾÁË×ÔÉíÃâÒß²¡µÄÖ²¡Ð»úÔìºÍÐÂÀíÂÛ£¬Îª´úлÎィÊÎÐγÉÐÂÉú¿¹Ô¡¢ÓÕ·¢×ÔÉíÃâÒß²¡µÄ²¡Òò²¡Àíѧ×êÑе춨ÁËÖÁ¹Ø³ÁÒªµÄ»ù´¡¡£Óë´Ëͬʱ£¬¸Ã×êÑжÔÓÚ³ÉÁ¢ASµÈÃâÒß²¡×ÔÉí¿¹ÔÌØÒìÐÔɸ²éºÍÕë¶ÔÐÔÒ½ÖÎÕ½ÊõÓµÓгÁ´óÒâ˼¡£

ͬÆÚ£¬ScienceÔÓÖ¾»¹°ä·¢ÁËһƪרÃÅÆÀÊöÎÄÕ£ºAutoimmunity to the modified self¡£¸ÃÆÀÂÛ³ö¸ñÖ¸³ö£¬´óÁ¿×êÑÐÒѾ·¢ÏÖ·Òëºó½¨ÊÎÔÚÑ×Ö¢ºÍ´úл¹ý³ÌÖб»¿í·º¼à²âµ½£¬×ÔÉíµ°°×PTMÊÇ×ÔÉíÃâÒߵijÁÒªÆðÔ´¡£Ëæ×ż¼ÊõµÄ²»ÐݽøÈ¡ºÍ×êÑеÄÉî¿Ì£¬ÓÐÍû·¢ÏÖ¸ü¶àµÄÓÕµ¼×ÔÉíÃâÒß·´Ó³µÄPTM¡£
£¨ÎÄÕÂÁ´½Ó£ºhttps://www.science.org/doi/10.1126/science.abg2482£©
´Ëǰ£¬ÔÚ2023Äê1ÔÂ12ÈÕ£¬³ÂÁÁ½ÌÊÚ×÷ΪͨѶ×÷Õߣ¬Óë¿Õ¾ü¾üÒ½´óѧÖìÆ½½ÌÊÚ£¬±ß»Ý½à½ÌÊÚ£¬ÉîÛÚÊеÚÈýÈËÃñÒ½ÔºÁõӳϼ½ÌÊÚ£¬Â¬ºéÖÞ½ÌÊÚºÏ×÷£¬ÔÚ¡¶Signal Transduction and Targeted Therapy¡·£¨IF=38£©ÔÚÏß°ä·¢ÌâΪ¡°Immunological and metabolic characteristics of the Omicron variants infection¡±µÄ×êÑÐÂÛÎÄ£¬ÏµÍ³µØ×êÑÐÁËOmicron±äÒìϰȾµÄÃâÒߺʹúÐ»ÌØµã¡£

ÔÚÕâÏî×êÑÐÖУ¬Í¨¹ý¶ÔMHC½áºÏëĶεÄÖÊÆ×·ÖÎö£¬·¢ÏÖOmicron±äÌåµÄ´ÌÍ»µ°°×Äܹ»²úÉú¶î±íµÄCD8+ Tϸ°û±í룬²¢ÓÕµ¼Ç¿ÁÒµÄCD8+ Tϸ°û·´Ó³¡£×êÑл¹·¢ÏÖ£¬¼ÓÇ¿ÒßÃç½ÓÖÖÄܹ»Ôö³¤½»²æÓ°ÏóCD8+ Tϸ°û¶ÔOmicronµÄ·´Ó³¡£´úлµ÷½Ú×é·ÖÎöÏÔʾ£¬³¬Î¢ÌØÒìÐÔTϸ°ûÓµÓÐÍÆ½øÓ°ÏóÐÔTϸ°û·´Ó³µÄ´úÐ»ÌØµã¡£Í¬Ê±£¬Ó°ÏóCD8+ Tϸ°û´æÔÚÓÚOmicron´Ì¼¤µÄ±íÖÜѪµ¥¸öºËϸ°û(PBMCs)ÖС£´Ë±í£¬×êÑл¹·¢ÏÖ£¬CD147ÊÇOmicron±äÌåµÄÊÜÌ壬CD147¿¹ÌåÄܹ»ÒÖÔìOmicronµÄϰȾ¡£ÔÚÈËCD147ת»ùÒòÓ×ÊóÄ£ÐÍÖУ¬CD147½éµ¼µÄOmicronϰȾ»áÓÕµ¼Éø³öÐÔ·ÎÅÝ·ÎÑס£¸Ã×êÑÐÅú×¢ÒßÃç¼ÓÇ¿¼ÁºÍÊÜÌå×è¶Ï¿¹ÌåÊÇÆ¥µÐOmicron±äÒìµÄÁ½ÖÖÓÐЧսÊõ¡£

¸Ã×êÑеķ¢ÏÖ½øÒ»²½¼ÓÇ¿Á˶ÔOmicron±äÒìÖêµÄÃâÒß¡¢²¡ÀíºÍ´úл»úÔìµÄÀí½â¡£ÕâЩ»úÔì¿ÉÄÜÚ¹ÊÏçËOmicronµÄÁÙ´²Ö¢×´£¬²¢Åú×¢ÒßÃç¼ÓÇ¿¼ÁÄܹ»ÓÐЧµØ±£»¤ËÞÖ÷ÃâÊÜSARS-CoV-2±äÌåϰȾ¡£Òò¶ø£¬¸Ã×êÑÐΪ³ÖÐøÆÀ¹À½«À´²¡¶¾±äÒìÈôºÎÌӱܿ¹ÌåºÍTϸ°ûÃâÒß·´Ó³ÌṩÁËÖ¤¾Ý£¬ÕâÒ²½øÒ»²½Ö¤ÁËȻͨÓÃÊÜÌå×è¶ÏÒ©ÎïµÄ¿ª·¢ÊǼ«¶È±ØÒªµÄ¡£
£¨ÎÄÕÂÁ´½Ó£ºhttps://www.nature.com/articles/s41392-022-01265-8£©

³ÂÁÁ½ÌÊڳ־ôÓÊÂÃâÒßÓëÉúÎïÐÅϢѧµÈ½»²æÑ§¿ÆÁìÓò×êÑУ¬ÔÚTϸ°ûÌØÒìÐÔÃâÒß¡¢Tϸ°ûÒ½Öεȷ½Ãæ»ñµÃϵÁгÁÒª·¢ÏÖ£¬´ú±íÐԳɾͰ䷢ÔÚScience¡¢STTT¡¢Nature Cell Biology¡¢Nature Immunology¡¢Journal of ImmunologyµÈ¹ú¼Êҽѧ¼°ÃâÒßѧ¶¥¼¶ÔÓÖ¾¡£