½üÈÕ£¬Ð±¦GGÐÔÃü¿ÆÑ§Ñ§Ôº¡¢Ð±¦GGÐÄѪ¹Ü×êÑÐËù³ÂÑ©Èð/±´ÒãèëÔÚACS Nano (IF=15.8)ÔÓÖ¾ÔÚÏß°ä·¢ÁËÌâΪ¡°Nanoparticle¨CPatch System for Localized, Effective, and Sustained miRNA Administration into Infarcted Myocardium to Alleviate Myocardial Ischemia¨CReperfusion Injury¡±µÄ×îÐÂ×êÑгɾͣ¨https://pubs.acs.org/doi/10.1021/acsnano.3c08811£©¡£¸Ã×êÑй¹½¨ÁËÒ»ÖÖÓɵ¼µç΢ÕëÌùƬ¸ºÔصÄmiRNAÄÉÃ×µÝËÍϵͳ£¬Í¨¹ýmiR-30dÔÚ¹£ÌúÐļ¡´¦µÄ²¿ÃÅ¡¢¸ßЧºÍ³ÖÐø¸øÒ©£¬¸ÄÉÆÐļ¡È±ÑªÔÙ¹àעΣÏÕ£¨Í¼1£©¡£Ð±¦GGÐÔÃü¿ÆÑ§Ñ§Ôº±´Òãèë½ÌÊں͸£½¨Ò½¿Æ´óѧ´ÓÊôкÍÒ½ÔºÐÄÄڿƳÂÕÑÑôÖ÷ÈÎΪ¹²Í¬Í¨Ñ¶×÷Õߣ¬ÇàÀÏ´óʦ³ÂÑ©Èð¡¢²©Ê¿Éú³Âº½ºÍ˶ʿÉúÖìÀûÔÆÎª¹²Í¬µÚÒ»×÷Õߣ¬Ð±¦GGΪµÚһʵÏÖµ¥Ôª¡£

ͼ1
Ð£ÉíºóѪÁ÷ÔÙ¹à×¢»áÒý·¢Ðļ¡È±ÑªÔÙ¹àעΣÏÕ£¬ÕâÊÇĿǰÁÙ´²Ò½ÖÎÖÐÉÐδ½â¾öµÄÎÊÌâ¡£ÔÚÐļ¡È±ÑªÔÙ¹àעΣÏյĴ´Ð½¨¸´Õ½ÊõÖУ¬microRNAs£¨miRNA£©ÓÐÍû³ÉΪ½¨¸´ÊÜËðÐĻùÒòÒ½Öι¤¾ß¡£¸ÃÍŶÓǰÆÚ×êÑз¢ÏÖ£¬miR-30dÔÚÐļ¡Ï¸°ûÖеĹý±í°×Äܹ»ÒÖÔìÐļ¡È±ÑªÔÙ¹àעΣÏÕºóµÄÐļ¡Ï¸°ûµòÍöºÍÏËά»¯¡£Ö»¹Ü³£¼ûµÄ²½ÖèÈçÖ¬ÖÊÌåºÍ²¡¶¾ÔØÌåÒѱ»ÓÃÓÚmiRNAתȾ£¬µ«ËüÃǵÄÒ½ÖÎЧÄÜÒ»Ïò±»½ÏµÍµÄÌåÄÚµÝËÍЧÄÜ¡¢miRNAÒ×ʧ»îÒÔ¼°ÃâÒßÔÐÔËùÏÞ¡£¸ÃÎijÉÁ¢ÁËÒ»¸öµ¼µç΢ÕëÌùƬ£¬²¢ÓÃÆä¸ºÔØ»ùÓÚZIF-8ÄÉÃ×Á£×ÓµÄmiR-30dÄÉÃ×µÝËÍϵͳ£¬Ò½ÖÎÓ×ÊóÐļ¡È±ÑªÔÙ¹àעΣÏÕ¡£ZIF-8ÄÉÃ×Á£×Óͨ¹ý×ÔÉíµÄÖÊ×Óº£ÃàЧӦԮÊÖmiR-30d´ÓÈÜøÌåÖÐÌÓÒÝ£¬´Ó¶øÔ¤·ÀÆä¹ýÔç½µ½âʧ»î¡£Óë´Ëͬʱ£¬µ¼µç΢ÕëÌùƬΪÐļ¡ÄÚ¸øÒ©ÌṩÖÕ²¿ÃÅ¡¢¸ßЧºÍ³ÖÐøµÄmiR-30dµÝËÍ£¬²¢¿ªÊͽðÄÉÃ×Á£×ÓÀ´³Á½¨¹£ËÀÇøÓòÄڵĵ紫µ¼¡£Ó×ÊóÐij¬ºÍÐĵçͼÁ˾ÖÏÔʾ£¬¸ºÔØmiRNAÄÉÃ×µÝËÍϵͳµÄ΢ÕëÌùƬֲÈëÓ×ÊóÐÄÔà3ÖܺÍ6Öܺó£¬Ó×ÊóÐÄÖ°Äܵõ½¸ÄÉÆ£¬ÐÄÔà³Á¹¹¼õÇá¡£
¸Ã×êÑй¤×÷µÃµ½Á˹ú¶È³ÁµãÑз¢´òËã¡¢¹ú¶ÈÌìÈ»¿ÆÑ§»ù½ð¡¢ÉϺ£ÊпÆÎ¯¡¢¸£½¨Ê¡ÇàÄêÈ˲ÅÔÞÖú´òËãµÈÏîÖ÷ÕÅ´óÁ¦ÔÞÖúºÍÖ§³Ö¡£¹þ·ð´óѧºÍÂÞÂíÄáÑÇAlessandrescu Rusescu¹ú¶ÈĸӤ½¡È«×êÑÐËùµÈ×êÑÐÕßÒ²²Î¼ÓÁ˸Ã×êÑС£
×ÛÉÏ£¬¸ÃÎĽáºÏÁ˵¼µç΢ÕëÌùƬºÍmiRNAÄÉÃ×µÝËÍϵͳµÄÓÅÊÆ£¬¿Ë·þÁ˳£¼ûmiRNAתȾ²½ÖèµÄ¾ÖÏÞÐÔ£¬ÊµÏÖÁËmiR-30dÔÚÐļ¡Ï¸°ûÖеIJ¿ÃÅ¡¢¸ßЧºÍ³ÖÐøµÄ±í°×¡£