ÀíѧԺÀ½ÌÊÚÍŶÓÔÚ¡¶Angewandte Chemie International Edition¡·°ä·¢×îÐÂ×êÑгɾÍ

°ä²¼¹¦·ò£º2024-09-06Ͷ¸å£º¹¨»ÝÓ¢ ²¿ÃÅ£ºÀíѧԺ ä¯ÀÀ´ÎÊý£º

½üÈÕ£¬ÀíѧԺ»¯Ñ§Ï·½ÌÊÚÍŶÓÔÚ¹ú¼Ê³ÛÃûÆÚ¿¯¡¶Angewandte Chemie International Edition¡·Éϰ䷢ÌâΪ¡¶Chemoselective Construction of Polycyclic Heterocycles Containing a [6-6-5] or [7-6-5] Tricyclic Core Skeleton from a 2-Isocyanophenyl Propargylic Ester¡·µÄ×êÑгɾÍ¡£Ë¶Ê¿Éú·ÑÓÐÎÄ¡¢ÖÜ×ÓºÀºÍÄß×ÓêÏΪ¹²Í³Ò»×÷£¬ÛªöÎÒ«½ÌÊںʹÞÀ׸±½ÌÊÚΪÂÛÎĵĹ²Í¬Í¨Ñ¶×÷Õß¡£Ð±¦GGΪµÚÒ»×÷Õßµ¥ÔªºÍͨѶ×÷Õßµ¥Ôª¡£

20240905-1.jpg

º¬ÓÐ[6-6-5]ºÍ[7-6-5]Ö÷Ìâ¹Ç¼ÜµÄ¶à»·»¯ºÏÎïÒòÆä½á¹¹¹ÖÒìºÍ³ÁÒªµÄÉúÀí»îÐÔ¶ø±¸Êܺϳɻ¯Ñ§¼ÒµÄ¹Ø×¢¡£ÓÉÓÚ¸ÃÀà¶à»·»¯ºÏÎï·Ö×ӽṹ¸´ÔÓ£¬Í¨³£±ØÒª¶à²½·´Ó³ÄÜÁ¦ºÏ³É£¬Òò¶ø·¢Õ¹Ò»²½ºÏ³ÉÒÔÉ϶໷¹Ç¼ÜµÄ¸ßЧ²½Ö轫Ϊ»¯Ñ§¡¢Ò½Ò©µÈÁìÓòµÄ×êÑÐÌṩ¼«·çÑűã¡£ÁíÒ»·½Ã棬¹ÙÄÜ»¯ÒìëæÔÚ¹¹½¨¶àÑù»¯º¬µªÔÓ»··½ÃæÓµÓÐÏÔÖøÓÅÊÆ£¬ÒìÇèËáõ¥¡¢Áª±½ÒìëæºÍÉ«°·ÒìëæµÈ´ú±íÐÔÒìëæÇ°ÌåÔÚ»·»¯·´Ó³ÖеÄÀûÓñ»´óÁ¿±¨Â·¡£Ö»¹ÜÈç´Ë£¬¹ÙÄÜ»¯Òìëæ»¯Ñ§µÄ·¢Õ¹ÒÀÈ»Ãæ¶Ô·´Ó³Ä£Ê½µ¥Ò»¡¢ºÏ¹¦Ð§Äܲ»¸ßÒÔ¼°¸´ÔÓÐÔ/¶àÑùÐÔ²»¼°µÈÌôÕ½£¬³ö¸ñÊÇÔÚ¸´ÔÓ¶à»·»¯ºÏÎïºÏ³ÉÁìÓòµÄÀûÓÃÊܵ½Öî¶àÏÞ¶È¡£

20240905-2.jpg

ΪÏàʶ¾öÉÏÊöÎÊÌ⣬À½ÌÊÚÍŶӳõ´ÎÉè¼ÆºÏ³ÉÁËÒ»Àà½á¹¹ÐÂÏʵĹÙÄÜ»¯ÒìëæÇ°Ìå-Ȳ±û´¼õ¥·¼»ùÒìëæ£¬²¢×êÑÐÁËÆäÓë2-°±»ù£¨ôÇ»ù£©·¼»ùÑǰ·õ¥µÄ·´Ó³¡£¸Ã·´Ó³Ç°ÌáºÍÉÆ£¬µ×ÎïºÏÓÃÐԺ㬿ÉÒ»´Î¹¹½¨Èý¸öл·£¬ÌṩÁ˺ϳÉà­ßø²¢2-ÇâßÅßᣨ±½²¢ß»à«£©¶à»·»¯ºÏÎïµÄв½Öè¡£ÒýÈËÖõÖ÷ÕÅÊÇ£¬È²±û´¼õ¥·¼»ùÒìëæÓë2-°±»ù·¼»ùÑǰ·õ¥ÔÚ¼îÐÔǰÌáÏ»¹Äܹ»ÌìÉúÁíÒ»Öֽṹ±ðÖµIJ¢»·»¯ºÏÎ¸Ã²úÆ·½á¹¹ÖÐÔ̺¬[7-6-5]Ö÷Ìâ¹Ç¼ÜºÍÒ»¸ö¼¾Ì¼ÖÐÐÄ¡£DFTÍÆËã·ÖÎöÅú×¢£¬È²±û´¼õ¥·¼»ùÒìëæÔÚ·´Ó³¹ý³ÌÖлá²úÉúÒ»Àà¸ßÕÅÁ¦µÄ»·±ûÏ©Ñǰ·ÖÐÑëÌ壬¿ÉÇл»µÄÇ׺˽ø¹¥/À©»·/·¼Ï㻯¹ý³ÌºÍÇ׺˼ӳÉ/À©»·/½â³ýµ¼ÖÂÁË·´Ó³¹ý³ÌÖÐ·ÖÆçµÄ²úÆ·Ñ¡ÔñÐÔ¡£»úÀí³¢ÊÔ½øÒ»²½Ö¤ÊµÁË»·±ûÏ©Ñǰ·ÖÐÑëÌåµÄ´æÔÚ¡£ÒÔÉÏ·´Ó³Äܹ»¸ßЧºÏ³ÉͨÀý²½ÖèÄÑÒÔ»ñµÃµÄ[6-6-5]ºÍ[7-6-5]Ö÷Ìâ½á¹¹¶à»·»¯ºÏÎ¸Ã¹¤×÷ÍØÕ¹ÁËÒìëæ»¯Ñ§µÄ×êÑÐÄÚÈÝ£¬Ò²Îª¸´ÔÓ¶à»·»¯ºÏÎïµÄºÏ³ÉÌṩÁËÐÂ˼·¡£

ÉÏÊö¹¤×÷µÃµ½¹ú¶ÈÌìÈ»¿ÆÑ§»ù½ðÏîÄ¿¡¢ÉϺ£ÊÐÌìÈ»¿ÆÑ§»ù½ðÏîÖ÷ÕÅÔÞÖú¡£

ÂÛÎÄÁ´½Ó£ºhttps://onlinelibrary.wiley.com/doi/10.1002/anie.202414726 

¡¾ÍøÕ¾µØÍ¼¡¿